86432-33-9

Basic information

• Product Name: (S)-3-(1H-Indol-3-yl)-2-(4-phenyl-butyrylamino)-propionic acid
• Synonyms: (S)-3-(1H-Indol-3-yl)-2-(4-phenyl-butyrylamino)-propionic acid
• CAS NO: 86432-33-9
• Molecular Weight: 350.417
• Mol File: 86432-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-(1H-Indol-3-yl)-2-(4-phenyl-butyrylamino)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(1H-Indol-3-yl)-2-(4-phenyl-butyrylamino)-propionic acid(86432-33-9)
• EPA Substance Registry System: (S)-3-(1H-Indol-3-yl)-2-(4-phenyl-butyrylamino)-propionic acid(86432-33-9)

Safety Data

• Hazardous Substances Data: 86432-33-9(Hazardous Substances Data)

Upstream product

• 88556-26-7 phenylbutyric acid N-hydroxysuccinimide ester 
• 73-22-3 L-Tryptophan 
• 1821-12-1 4-Phenylbutyric acid 
• 18496-54-3 phenylbutyric acid chloride 
• 54-12-6 Trp 

Downstream Products

• 142907-06-0 1-(3-phenylpropyl)-3,4-dihydro-β-carboline-3-carboxylic acid 

Relevant articles and documents

Carbamic acid compounds comprising an amide linkage as hdac inhibitors

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the formula (1) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: —NR1C(═O)—and —C(═O)NR1—; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.