86433-38-7Relevant academic research and scientific papers
Certain piperidino-lower-alkylene esters of 3-methylflavone-8-carboxylates possessing smooth muscle relaxant activity
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, (2008/06/13)
Novel 3-methylflavone-8-carboxylates having the structural formula (I): STR1 wherein Z is N-methylpiperidinyl, tropinyl or quinuclidinyl, or a group having the structural formula (II): STR2 in which n is 0 or 1, R is hydrogen or alkyl having from 1 to 4 carbon atoms, or phenyl, R1 is hydrogen or alkyl having from 1 to 4 carbon atoms, R2 is hydrogen or hydroxy, and further wherein R, R1 and R2 may together form, with the carbon atoms from which they depend, a cycloalkyl ring having from 4 to 6 carbon atoms, and R3 is hydrogen or alkyl having from 1 to 4 carbon atoms, with the proviso that R, R1, R2 and R3 cannot at the same time all be hydrogen, and the pharmaceutically acceptable salts thereof, are effective smooth muscle relaxants, calcium blockers, anaesthetics and anti-inflammatories.
