864386-11-8

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-
• Synonyms: 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-
• CAS NO: 864386-11-8
• Molecular Formula: C28H34N6O4
• Molecular Weight: 518.61
• Mol File: 864386-11-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 740.2±70.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 7.86±0.10(Predicted)
• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-(864386-11-8)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-(864386-11-8)

Safety Data

• Hazardous Substances Data: 864386-11-8(Hazardous Substances Data)

Relevant articles and documents

PYRIMIDINE DERIVATIVE

This invention provides pyrimidine derivatives represented by a formula, in the formula, ring A stands for carbocyclic group or heterocyclic group, X 1 stands for hydrogen, lower alkyl, amino, etc., X 2 stands for hydrogen or lower alkyl, Y stands for a direct bond or sulfur or nitrogen, n stands for an integer of 0 - 4, and Ar stands for a group of the following formula, or a salt thereof, which concurrently exhibit 5-HT 1A agonistic activity and 5-HT 3 antagonistic activity and are useful for therapy and treatments of diseases such as IBS. The invention furthermore provides a therapeutic method of IBS, characterized by having 5-HT 1A agonistic activity and 5-HT 3 antagonistic activity work simultaneously and cooperatively in vivo, which comprises either administering 5-HT 3 antagonistic agent which concurrently exhibits 5-HT 1A agonistic activity, or administering 5-HT 1A agonistic agent and 5-HT 3 antagonistic agent simultaneously, in sequence or at an interval.