864423-16-5Relevant academic research and scientific papers
3,3′-disubstituted BINAP ligands: Synthesis, resolution, and applications in asymmetric hydrogenation
Hopkins, J. Matthew,Dalrymple, Sean A.,Parvez, Masood,Keay, Brian A.
, p. 3765 - 3768 (2005)
(Chemical Equation Presented) A novel family of BINAP ligands were prepared with alkoxy- and acetoxy-derived substituents in the 3,3′-positions. They were prepared through a convergent synthesis starting from readily available 4-bromo-2-naphthol. These ligands afforded excellent enantioselectivities in the asymmetric hydrogenation of substituted olefins. The presence of the 3,3′-substituents was shown to be beneficial by a direct comparison with the parent unsubstituted BINAP.
