864433-81-8

Basic information

• Product Name: 3-[(E)-1-Hydroxy-3-(2-nitro-phenyl)-prop-2-en-(Z)-ylidene]-2-methyl-chroman-4-one
• CAS NO: 864433-81-8
• Molecular Weight: 337.332
• Mol File: 864433-81-8.mol

Chemical Properties

• CAS DataBase Reference: 3-[(E)-1-Hydroxy-3-(2-nitro-phenyl)-prop-2-en-(Z)-ylidene]-2-methyl-chroman-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(E)-1-Hydroxy-3-(2-nitro-phenyl)-prop-2-en-(Z)-ylidene]-2-methyl-chroman-4-one(864433-81-8)
• EPA Substance Registry System: 3-[(E)-1-Hydroxy-3-(2-nitro-phenyl)-prop-2-en-(Z)-ylidene]-2-methyl-chroman-4-one(864433-81-8)

Safety Data

• Hazardous Substances Data: 864433-81-8(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 52162-78-4 (E)-3-(2-nitrophenyl)acryloyl chloride 
• 864433-66-9 (2Z,4E)-3-Hydroxy-1-(2-hydroxy-phenyl)-5-(2-nitro-phenyl)-penta-2,4-dien-1-one 
• 864433-73-8 2-Methyl-3-[(E)-3-(2-nitro-phenyl)-acryloyl]-chromen-4-one 

Relevant articles and documents

Synthesis of 3-alkenyl-2-arylchromones and 2,3-dialkenylchromones via acid-catalysed retro-Michael ring opening of 3-acylchroman-4-ones

3-Acylchromones and 3-acylflavones, readily available by acylation of 2′-hydroxydibenzoylmethane with acid anhydrides in the presence of base, undergo efficient conjugate reduction with NaBH4 in pyridine to give the corresponding chroman-4-ones/flavanones in high yields. The reduction is both regio- and chemoselective. Treatment of the chroman-4-ones with MeSO 3H generates the 3-alkenyl-2-arylchromones by a dehydrative rearrangement initiated by retro-Michael cleavage of the pyranone ring. This reduction-rearrangement sequence can be extended to 2-alkyl-3-alkenoylchromones to generate 3-alkenyl-2-styrylchromones, the first examples of 2,3-dialkenylchromones.