864434-18-4

Basic information

• Product Name: N-[2-(3,4-dimethoxyphenyl)ethyl]pyrimidin-2-amine
• Synonyms: N-[2-(3,4-dimethoxyphenyl)ethyl]pyrimidin-2-amine
• CAS NO: 864434-18-4
• Molecular Formula: C₁₄H₁₇N₃O₂
• Molecular Weight: 259.3
• Mol File: 864434-18-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 429.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]pyrimidin-2-amine(864434-18-4)
• EPA Substance Registry System: N-[2-(3,4-dimethoxyphenyl)ethyl]pyrimidin-2-amine(864434-18-4)

Safety Data

• Hazardous Substances Data: 864434-18-4(Hazardous Substances Data)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 1042275-24-0 2-(4-chlorophenyl)-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy-3-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide 

Relevant articles and documents

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.