864445-60-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(2-Bromophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone is used as a synthetic cannabinoid for its ability to potently activate the central CB1 and peripheral CB2 receptors. This makes it a promising candidate for the development of novel therapeutic agents targeting various medical conditions, such as pain management, inflammation, and neurological disorders.
Used in Research Applications:
In the field of scientific research, 2-(2-Bromophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone serves as a valuable tool for studying the mechanisms of action and signaling pathways associated with CB1 and CB2 receptors. This can help researchers gain a deeper understanding of the endocannabinoid system and its role in various physiological processes and diseases.
Used in Drug Development:
The unique structure and receptor-binding properties of 2-(2-Bromophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone make it a potential lead compound for the development of new drugs targeting the endocannabinoid system. By optimizing its chemical structure and pharmacological properties, researchers can potentially develop more effective and safer therapeutic agents for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 864445-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,4,4 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 864445-60:
(8*8)+(7*6)+(6*4)+(5*4)+(4*4)+(3*5)+(2*6)+(1*0)=193
193 % 10 = 3
So 864445-60-3 is a valid CAS Registry Number.
864445-60-3Relevant articles and documents
1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles
Huffman, John W.,Szklennik, Paul V.,Almond, Amanda,Bushell, Kristen,Selley, Dana E.,He, Hengjun,Cassidy, Michael P.,Wiley, Jenny L.,Martin, Billy R.
, p. 4110 - 4113 (2007/10/03)
A new class of cannabimimetic indoles, with 3-phenylacetyl or substituted 3-phenylacetyl substituents, has been prepared and their affinities for the cannabinoid CB1 and CB2 receptors have been determined. In general those compounds with a 2-substituted phenylacetyl group have good affinity for both receptors. The 4-substituted analogs have little affinity for either receptor, while the 3-substituted compounds are intermediate in their affinities. Two of these compounds, 1-pentyl-3-(2-methylphenylacetyl)indole (JWH-251) and 1-pentyl-3-(3-methoxyphenylacetyl)indole (JWH-302), have 5-fold selectivity for the CB1 receptor with modest affinity for the CB 2 receptor. GTPγS determinations indicate that both compounds are highly efficacious agonists at the CB1 receptor and partial agonists at the CB2 receptor.
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