864461-16-5Relevant articles and documents
Chemoselective arylamidine cyclizations: Mild formation of 2-arylimidazole-4-carboxylic acids
Yoburn, Joshua C.,Baskaran, Subramanian
, p. 3801 - 3803 (2005)
(Chemical Equation Presented) A versatile, one-pot synthesis of 2-arylimidazole-4-carboxylic acids from arylamidines and methyl-2- chloroacetoacetate is described. The transformation is chemoselective, and reaction conditions are mild. Moreover, the flexibility of the strategy offers rapid access to two important classes of biaryl compounds, both 2-arylimidazoles and 2-arylpyrimidmes, depending simply upon solvent and base selection.