864463-31-0Relevant academic research and scientific papers
Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of α,β-disubstituted unsaturated acids
Hoen, Rob,Boogers, Jeroen A. F.,Bernsmann, Heiko,Minnaard, Adriaan J.,Meetsma, Auke,Tiemersma-Wegman, Theodora D.,De Vries, Andre H. M.,De Vries, Johannes G.,Feringa, Ben L.
, p. 4209 - 4212 (2005)
(Chemical Equation Presented) Mixing it up: A catalytic system based on a mixed-ligand approach has been developed for the rhodium-catalyzed asymmetric hydrogenation of cinnamic acid derivatives (see scheme, cod = cycloocta-1,5-diene). It is the first time that a catalyst complex based on a heterocombination of a chiral and an achiral monodentate ligand gives dramatically higher enantioselectivity (up to 99%) than any of the corresponding homocomplexes.
