864465-64-5Relevant academic research and scientific papers
Total synthesis of 4-ketoclonostachydiol
Yadav, Jhillu Singh,Vardhan, Vijaya,Das, Saibal
, p. 2347 - 2352 (2014)
A facile total synthesis of nonsymmetrical 14-membered macrocyclic bis-lactone, 4-ketoclonostachydiol has been demonstrated in a convergent approach. The synthetic strategy has been unambiguously successful towards incorporating all the three stereogenic centers present in the molecule with an overall yield of 0.9%. The key synthetic step includes MacMillan hydroxylation and Grubbs ring-closing metathesis reactions to furnish the core skeleton. Georg Thieme Verlag Stuttgart.New York.
Stereoselective total synthesis of 4-ketoclonostachydiol
Rajaram, Singanaboina,Ramulu, Udugu,Ramesh, Dasari,Prabhakar, Peddikotla,Venkateswarlu, Yenamandra
, p. 2115 - 2123 (2013/12/04)
An efficient stereoselective total synthesis of the bioactive 14-membered natural macrocyclic bislactone 4-ketoclonostachydiol is described. The strategy involves a Jacobsen's hydrolytic kinetic resolution (HKR), epoxide opening, MacMillan α-hydroxylation, Horner-Wadsworth-Emmons olefination, a Grignard reaction, and Hoveyda-Grubbs-II-catalyzed ring-closing metathesis (RCM) as key steps.
Asymmetric total synthesis and revision of the absolute configuration of 4-keto-clonostachydiol
Han, Junjie,Su, Yingpeng,Jiang, Tuo,Xu, Yanfen,Huo, Xing,She, Xuegong,Pan, Xinfu
supporting information; experimental part, p. 3930 - 3932 (2009/10/14)
(Chemical Equation Presented) The first total synthesis of the 14-membered natural macrocyclic bislactone 4-keto-clonostachydiol, along with its enantiomer, has been accomplished in 13 steps with overall yields of 8.4% and 8.0%, respectively. The absolute
