864466-71-7

Basic information

• Product Name: (S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine
• Synonyms: (S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine;S-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine;(S)-()-α,α-Diphenyl-2-pyrrolidineMethanol tert-butyldiMethylsilyl ether >=97% (HPLC);2-(S)-[(DIPHENYL)(t-BUTYLDIMETHYLSILOXY)METHYL]PYRROLIDINE;(S)-2-[(tert-ButyldiMethylsiloxy)diphenylMethyl]pyrrolidine;(S)-2-(((tert-Butyldimethylsilyl)-oxy)diphenylmethyl)pyrrolidine;(S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether;(S)-(?)-α,α-Diphenylprolinol tert-butyldimethylsilyl ether
• CAS NO: 864466-71-7
• Molecular Formula: C23H33NOSi
• Molecular Weight: 367.61
• Mol File: 864466-71-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 71-73°C
• Boiling Point: 445.2±35.0 °C(Predicted)
• Flash Point: >110°C (>230°F)
• Appearance: /
• Density: 0.998±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.12±0.10(Predicted)
• BRN: 10368174
• CAS DataBase Reference: (S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine(864466-71-7)
• EPA Substance Registry System: (S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine(864466-71-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 864466-71-7(Hazardous Substances Data)

Usage

General Description

The chemical "(S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine" is a compound that contains a pyrrolidine ring and a siloxane group. It is a chiral molecule, with a specific three-dimensional arrangement of atoms. The compound is used in various chemical and pharmaceutical applications, particularly in the synthesis of potential drug candidates. Its specific structure and properties make it a useful building block in organic synthesis, enabling the creation of diverse molecules with specific functionalities. The compound's unique combination of a pyrrolidine ring, diphenyl, and a t-butyldimethylsiloxymethyl group also makes it of interest in the development of new materials and specialty polymers.

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 77581-28-3 (S)-proline-N-ethyl carbamate methyl ester 
• 100-58-3 phenylmagnesium bromide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 22348-32-9 (R)-α,α-diphenylprolinol 
• 22348-32-9 (S)-diphenylprolinol 

Relevant articles and documents

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes

The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high diastereoselectivities. The synthetic utility of the protocol was exemplified on a set of additional transformations of the corresponding spiro compounds. In addition, a study showing the promising biological activity of selected enantioenriched products was accomplished.

KAHA ligations that form aspartyl aldehyde residues as synthetic handles for protein modification and purification

Aldehydes are widely recognized as valuable synthetic handles for the chemoselective manipulation of peptides and proteins. In this report, we show that peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easily p

Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

(Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtaine