864518-30-9Relevant academic research and scientific papers
Novel aromatic compounds and their use in medical applications
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Page/Page column 21, (2010/11/26)
Pharmaceutical compositions comprising at least one compound of the formulas (Ia) or (Ib) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents have the following meaning -X- is e.g. or or or and Y being or or the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formulas (Ia) or (Ib). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.
Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
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Page/Page column 20, (2008/06/13)
The compounds having the general structure of formula (I) wherein the symbols, indices and substituents have the following meaning if R2=OH and R3=H then R1=H, CN, NO2, CF3, F, Cl, Br, I, CH3 or if R3=OH and R2=H then R1=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, i-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl or if R3=OH and R1=H then R2=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl then X is e.g. ???with R4 being H, CH3, CH2CH3 or or ???and Y being or and the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formula (I). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.
