86453-96-5

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 86454-02-6 5-[1,2-Dibromo-2-(4-bromo-phenyl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 
• 1314231-01-0 5-(2-benzylsulfanyl-2-(4-bromophenyl)ethyl)-3-methyl-4-nitroisoxazole 
• 1380544-31-9 5-(4-bromophenethyl)-3-methyl-4-nitroisoxazole 
• 1426132-16-2 (2'R,3'S,4'S)-3'-(4-bromophenyl)-1-methyl-4'-(3-methyl-4-nitroisoxazol-5-yl)-5'-thioxospiro[indoline-3,2'-pyrrolidin]-2-one 
• 1426132-25-3 (2'R,3'S,4'S)-3'-(4-bromophenyl)-4'-(3-methyl-4-nitroisoxazol-5-yl)-1-phenyl-5'-thioxospiro[indoline-3,2'-pyrrolidin]-2-one 
• 1426132-27-5 (2'R,3'S,4'S)-3'-(4-bromophenyl)-1,5-dimethyl-4'-(3-methyl-4-nitroisoxazol-5-yl)-5'-thioxospiro[indoline-3,2'-pyrrolidin]-2-one 

Relevant academic research and scientific papers

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles

A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.

Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles

We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sul