86454-07-1Relevant academic research and scientific papers
Reaction of β-Aminocrotonamide with Dibasic Acid Derivatives
Sato, Masayuki,Ogasawara, Hiromichi,Kato, Tetsuzo
, p. 87 - 91 (2007/10/02)
Reaction of β-aminocrotonamide (1) with succinic anhydride gave β-succinamidocrotonamide (3a), which was treated with base to cyclize to 3,4-dihydro-6-methyl-4-oxo-2-pyrimidinepropanoic acid (4a).Similarly, pyrimidinepentanoic acid derivative 4b was prepared from compound 1 and glutaric anhydride.Reaction of compound 1 with dimethyl succinate in the presence of sodium methoxide gave the pyrimidine derivative 4a.Similar reaction of compound 1 with glutarate, adipate, and phthalate gave the corresponding pyrimidines 4b, 4c and 4d, while reaction of compound 1 with malon ate gave 2-hydroxypyridine derivative 11 and dimethylpyrimidinone 4e.Reaction of dimethyl fumarate with compound 1 in the presence of methoxide gave a poor yield of pyrrolopyridine derivative 13.
