86456-99-7

Upstream product

• 2538-98-9 4-isopropyloxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 1015426-19-3 (E)-1-isopropoxy-2-methoxy-4-(2-nitrovinyl)benzene 

Downstream Products

• 1015426-26-2 N-[2-(4-isopropoxy-3-methoxyphenyl)ethyl]formamide 
• 1256777-47-5 N-[2-(4-isopropoxy-3-methoxy-phenyl)-ethyl]-2-thiophen-2-yl-acetamide 
• 1256777-98-6 2-formamido-N-(4-isopropoxy-3-methoxyphenethyl)acetamide 
• 1177013-41-0 [2-(4-isopropoxy-3-methoxyphenyl)ethyl]ceramic acid allyl ester 
• 149486-95-3 N-[2-(3-Methoxy-4-isopropoxyphenyl)ethyl]-N'-(2-thiazolyl)thiourea 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

The synthesis of a new series of Erythrina alkaloid analogues and their pharmacological characterization at various nicotine acetylcholine receptor (nAChR) subtypes are described. The compounds were designed to be simplified analogues of aromatic erythrinanes with the aim of obtaining subtype-selective antagonists for the nAChRs and thereby probe the potential of using these natural products as scaffolds for further ligand optimization. The most selective and potent nAChR ligand to come from the series, 6,7-dimethoxy-2- methyl-1,2,3,4-tetrahydroisoquinoline (3c) (also a natural product by the name of O-methylcorypalline), displayed submicromolar binding affinity toward the α4β2 nAChR with more than 300-fold selectivity over α4β4, α3β4, and α7. Furthermore, this lead structure (which also has inhibitory activity at monoamine oxidases A and B and at the serotonin and norepinephrine transporters) showed antidepressant-like effect in the mouse forced swim test at 30 mg/kg.

(DIHYDRO) IMIDAZOISO (5, 1-A) QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS

The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula (1) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

(DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES

The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

(DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES

The invention relates to 5,6 - dihydropyrrolo [2,1-a] isoquinoline and pyrrolo[2,1-a] isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

Synthesis of both enantiomers of protoberberines via laterally lithiated (S)-4-isopropyl-2-(o-tolyl)-oxazolines

The addition of the laterally lithiated (S)-4-isopropyl-2-(o- tolyl)oxazoline (1) to 6,7-dimethoxy-3,4-dihydroisoquinoline (2) proceeded in modest diastereoselectivity. However, the addition products (3a) and (3b) were easily separated by column chromatography over silica gel. Acid-catalyzed lactamization of 3a and 3b followed by LiAlH4-reduction afforded the corresponding optically pure protoberberines (8a) and (8b), respectively. This procedure was successfully applied to the synthesis of both enantiomers of xylopinine and bharatamine.