86457-40-1

Basic information

• Product Name: C₂₁H₂₂N₂O₂
• CAS NO: 86457-40-1
• Molecular Weight: 334.418
• Mol File: 86457-40-1.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂N₂O₂(86457-40-1)
• EPA Substance Registry System: C₂₁H₂₂N₂O₂(86457-40-1)

Safety Data

• Hazardous Substances Data: 86457-40-1(Hazardous Substances Data)

Upstream product

• 10016-59-8 3,4-dihydro-4-phenylisoquinoline hydrochloride 
• 86457-11-6 (7α,11bα)-1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-one 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

Synthesis and Antihypertensive Activity of a Series of Spiroquinolizine-2,5'-oxazolidin-2'-one>s

The 2R*,11bS* and 2S*,11bS* diastereoisomers of the spiroquinolizine-2,5'-oxazolidin-2'-one> system were prepared by stereoselective methods.Evaluation of these compounds for antihypertensive activity by oral administration to the spontaneously hypertensive rat showed the 2S*,11bS* series was the more potent.Within that series it was found that small alkyl substituents at positions 3 and 4' enhanced antihypertensive activity and that methoxyl substitution at positions 9 and 10 was optical. (2S,3S,11bS)-Spiroquinolizine-2,5'-oxazolidin-2'-one> was one of the most efficacious compounds of this series, while its antipode, (+)-9e, was inactive.Selected compounds in this series were shown to be α-adrenoceptor antagonists.