864665-17-8

Basic information

• Product Name: C₂₁H₂₉FN₄O₆
• Synonyms: C₂₁H₂₉FN₄O₆
• CAS NO: 864665-17-8
• Molecular Weight: 452.483
• Mol File: 864665-17-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₉FN₄O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₉FN₄O₆(864665-17-8)
• EPA Substance Registry System: C₂₁H₂₉FN₄O₆(864665-17-8)

Safety Data

• Hazardous Substances Data: 864665-17-8(Hazardous Substances Data)

Upstream product

• 268209-15-0 tert-butyl 4-(4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate 
• 79-22-1 methyl chloroformate 

Downstream Products

• 864665-18-9 (5S)-((3-(3-fluoro-4-(piperazin-1-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)carbamic acid methylester 

Relevant articles and documents

Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents

Novel oxazolidinone antibacterials bearing a variety of 3-indolylglyoxamide substituents have been explored in an effort to improve the spectrum and potency of this class of agents. A subclass of this series was also made with the diversity at C-5 terminus. These derivatives have been screened against a panel of clinically relevant Gram-positive pathogens and fastidious Gram-negative organisms. Several analogs in this series were identified with in vitro activity superior to linezolid (MIC = 0.25-2 μg/mL). Compounds 10a, 10c, 10e and 10f displayed activity against linezolid resistant Gram-positive organisms (MIC = 2-4 μg/mL). Selected oxazolidinones were evaluated for in vivo efficacy against a mouse systemic infection model.