864677-96-3

Upstream product

• 136416-11-0 ethyl 3-[2-(3-hydroxypropyl)phenyl]propanoate 
• 378759-68-3 ethyl (E)-3-[2-(3-oxopropyl)phenyl]prop-2-enoate 
• 91047-77-7 ethyl (2E)-3-(2-bromophenyl)prop-2-enoate 
• 864677-87-2 C₁₇H₁₉BrO₂ 
• 864677-91-8 3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 6630-33-7 ortho-bromobenzaldehyde 

Relevant academic research and scientific papers

Access to a new family of medium ring aromatic lactones

We report a new method for preparation of hydroxyacids as precursors of benzolactones using a simple and an efficient electrochemical step. This gives in only four steps six- to eleven-membered lactones with high isolated yields from conveniently substituted aryl bromides. The lactonisation was performed according to the Yamamoto's process.

Synthesis of precursors for medium-ring aromatic lactones

Hydroxyacids have been prepared via the nickel-catalysed electrochemical arylation of ethyl acrylate from an ortho-substituted aryl bromide. Protection and deprotection steps have been selected in terms of suitability and efficiency. The lactonisation was