864684-79-7Relevant academic research and scientific papers
Synthesis, characterization and molecular docking of novel quinoline and pyridine derivatives
Saleh, Suheb,Al-Timari, Usama,Al-Fahdawi, Aeed,El-Khatatneh, Nasseem,Chandra,Mahendra,Al-Ghorbani6, Mohammed
, p. 2713 - 2719 (2018/02/20)
A new series of substituted quinoline and pyridine derivatives 6a-h are synthesized by the coupling of hydrazide derivatives 4a-b with substituted carboxylic acids 5a-c in the presence of N,N,N’,N’-tetramethyl-o-(benzotriazol-1-yl) uranium tetrafluoroborate TBTU as a coupling agent and lutidine as a base. The newly synthesized compounds 6a–l is characterized by analytical NMR and mass spectral data. The newly synthesized compounds were subjected to molecular docking studies for the inhibition of human Aurora A kinase target to evaluate their potential value for the treatment of cancers.
QUINOLINONE DERIVATIVES
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Page/Page column 53, (2012/09/22)
The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.
