864754-47-2 Usage
Uses
Used in Pharmaceutical Development:
2-[4-(2-Fluoro-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane is used as a synthetic reagent for the creation of pharmaceuticals, leveraging its ability to form crucial bonds in the molecular structures of potential drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-[4-(2-Fluoro-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane serves as a reagent in the synthesis of compounds designed to protect crops and enhance agricultural productivity.
Used in Materials Science:
2-[4-(2-Fluoro-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane is utilized as a component in the development of new materials, where its capacity to engage in various organic reactions contributes to the creation of innovative material properties.
Used for Fluorine Atom Introduction:
2-[4-(2-Fluoro-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane is used as a fluorination agent to introduce fluorine atoms into organic molecules across different chemical domains. The introduction of fluorine can significantly alter the pharmacological and physical properties of compounds, often enhancing their stability, reactivity, or bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 864754-47-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,7,5 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 864754-47:
(8*8)+(7*6)+(6*4)+(5*7)+(4*5)+(3*4)+(2*4)+(1*7)=212
212 % 10 = 2
So 864754-47-2 is a valid CAS Registry Number.
864754-47-2Relevant academic research and scientific papers
Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats
Ouach, Aziz,Vercouillie, Johnny,Bertrand, Emilie,Rodrigues, Nuno,Pin, Frederic,Serriere, Sophie,Boiaryna, Liliana,Chartier, Agnes,Percina, Nathalie,Tangpong, Pakorn,Gulhan, Zuhal,Mothes, Celine,Deloye, Jean-Bernard,Guilloteau, Denis,Page, Guylene,Suzenet, Franck,Buron, Frederic,Chalon, Sylvie,Routier, Sylvain
, p. 449 - 469 (2019/07/03)
In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The exploration of SAR required the preparation of uncommon boron derivatives. Forty final drugs were tested for their ability to bind the target and nine of them exhibited Ki values below nanomolar concentrations. The best scores were always obtained when the 5-phenyl-2-thiophenyl core was attached to the triazole. The selectivity of these compounds towards the nicotinic α4β2 and serotoninergic 5HT3 receptors was assessed and their brain penetration was quantified by the preparation and in vivo evaluation of two [18F] radiolabelled derivatives. It can be expected from our results that some of these compounds will be suitable for further developments and will have effects on cognitive disorders.
