864771-44-8

Basic information

• Product Name: TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE
• Synonyms: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxyla;1H-Indazole-5-boronic acid pinacol ester, N1-BOC protected;1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid pinacol ester;1-Boc-indazole-5-boronic acid pinacol ester;tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)- indazole-1-carboxylic acid tert-butyl ester;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate, 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
• CAS NO: 864771-44-8
• Molecular Formula: C₁₈H₂₅BN₂O₄
• Molecular Weight: 344.2131
• Product Categories: Indazoles
• Mol File: 864771-44-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 461.4°C at 760 mmHg
• Flash Point: 232.8°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 1.08E-08mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE(864771-44-8)
• EPA Substance Registry System: TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE(864771-44-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 864771-44-8(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE is a chemical compound that belongs to the class of indazole carboxylates. It is a derivative of indazole containing a tert-butyl ester group and a tetramethyl-1,3,2-dioxaborolan-2-yl substituent. TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE has potential use in pharmaceutical research and drug discovery due to its unique chemical structure and potential biological activities. However, more research is needed to fully understand its properties and potential applications in various fields.

InChI:InChI=1/C18H25BN2O4/c1-16(2,3)23-15(22)21-14-9-8-13(10-12(14)11-20-21)19-24-17(4,5)18(6,7)25-19/h8-11H,1-7H3

Upstream product

• 53857-57-1 5-bromo-1H-indazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 651780-02-8 tert-butyl 5-bromo-1H-indazole-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1210047-46-3 methyl 2-((4-(1H-indazol-5-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)-5-methoxybenzoate 
• 1396753-47-1 3-(benzyl(methyl)amino)-2-(1H-indazol-5-yl)quinoxaline-6-carboxylic acid 
• 1396753-51-7 methyl 3-(benzyl(methyl)amino)-2-(1H-indazol-5-yl)quinoxaline-6-carboxylate 
• 1396753-50-6 methyl 3-(benzyl(methyl)amino)-2-(1-(tert-butoxycarbonyl)-1H-indazol-5-yl)quinoxaline-6-carboxylate 
• 1396753-53-9 (S)-2-(1H-indazol-5-yl)-3-(methyl(1-phenylethyl)amino)quinoxaline-6-carboxylic acid 
• 1396753-56-2 (S)-methyl 2-(1H-indazol-5-yl)-3-(methyl(1-phenylethyl)amino)quinoxaline-6-carboxylate 
• 1426095-01-3 N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-5-yl)-N-methylbenzamide 
• 1426095-37-5 N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-5-yl)-N-(phenylmethyl)benzamide 
• 1422022-18-1 tert-butyl 5-(3-cyano-2-(3-methylthiophen-2-yl)-5-propylphenyl)-1H-indazole-1-carboxylate 
• 1167418-12-3 1-(tert-butoxycarbonyl)-1H-indazol-5-ylboronic acid 
• 906004-19-1 5-{5-[4-tert-butoxycarbonyl-2S-(4-fluoro-phenyl)-piperazin-1-ylmethyl]-pyridin-3-yl}-indazole-1-carboxylic acid tert-butyl ester 
• 906004-17-9 C₃₃H₃₄F₂N₄O₃ 
• 1338795-62-2 3-iodo-5-phenyl-1H-indazole 
• 185316-58-9 5-phenyl-1H-indazole 

Relevant articles and documents

PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS

Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to carboxamides and reverse carboxamides according to Formula (I) and the use of carboxamides and reverse carboxamides for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of carboxamides and reverse carboxamides in the treatment of cancer.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.