864775-43-9

Upstream product

• 270065-80-0 (3S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-[4-(trifluoromethyl)phenyl]butanoic acid 
• 1105710-19-7 (S)-3-amino-4-(4-(trifluoromethyl)phenyl)butan-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1105712-13-7 (S)-3-(tert-butoxycarbonylamino)-4-(4-(trifluoromethyl)phenyl)butyl methanesulfonate 
• 864775-46-2 1,1-dimethylethyl ((1S)-3-[(5-bromo-6-chloro-3-pyridinyl)oxy]-1-{[4-(trifluoromethyl)phenyl]methyl}propyl)carbamate 

Relevant academic research and scientific papers

HETEROCYCLIC MODULATORS OF PKB

The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

INHIBITORS OF AKT ACTIVITY

Invented are novel pyridine compounds, the use of such compounds as inhibitors of PKB/AKT kinase activity and in the treatment of cancer and arthritis.