864775-61-1

Usage

Structure

Pyrazole derivative with a pyridine ring and a methyl group attached to the nitrogen atom

Triphenylmethyl group

Three phenyl rings connected to a central carbon atom

Potential applications

Pharmacological and biological properties, possible use in drug development and medical treatments

Upstream product

• 76-83-5 trityl chloride 
• 194278-45-0 3-methyl-1H-pyrazolo[4,3-b]pyridine 
• 87674-20-2 1-(3-fluoropyridin-2-yl)ethanone 

Downstream Products

• 864775-64-4 5-chloro-3-methyl-1H-pyrazolo[4,3-b]pyridine 
• 864775-63-3 3-methyl-1-trityl-1H-pyrazolo[4,3-b]pyridine 4-oxide 

Relevant academic research and scientific papers

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

A novel series of AKT inhibitors containing 2,3,5-trisubstituted pyridines with novel azaindazoles as hinge binding elements are described. Among these, the 4,7-diazaindazole compound 2c has improved drug-like properties and kinase selectivity than those of indazole 1, and displays greater than 80% inhibition of GSK3β phosphorylation in a BT474 tumor xenograft model in mice.

INHIBITORS OF AKT ACTIVITY

Invented are novel pyridine compounds, the use of such compounds as inhibitors of PKB/AKT kinase activity and in the treatment of cancer and arthritis.