864776-75-0Relevant academic research and scientific papers
Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies
Hanashima, Shinya,Manabe, Shino,Ito, Yukishige
, p. 4218 - 4224 (2007/10/03)
(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl.
