864784-03-2Relevant academic research and scientific papers
Synthesis of 2-azaspiro[4.4]nonan-1-ones via phosphine-catalysed [3+2]-cycloadditions
Yong, Sarah R.,Williams, Morwenna C.,Pyne, Stephen G.,Ung, Alison T.,Skelton, Brian W.,White, Allan H.,Turner, Peter
, p. 8120 - 8129 (2007/10/03)
The phosphine-catalyzed [3+2]-cycloaddition of the 2-methylene γ-lactams 4 and 5 and the acrylate 6 with the ylides derived from the ethyl ester, the amide or the chiral camphor sultam derivative of 2-butynoic acid (7a-c) give directly, or indirectly after reductive cyclization, spiro-heterocyclic products. The acid 32 underwent Curtius rearrangement and then acid hydrolysis to give two novel spiro-cyclic ketones, 41 and 42.
