864814-88-0 Usage
Uses
Resminostat is an oral histone deacetylase (HDAC) inhibitor. It inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells.
Biological Activity
resminostat, also known as ras2410, is a potent inhibitor of histone deacetylase (hdac) classes i and ii (including hdac1, hdac3 and hdac6) with 50% inhibition concentration ic50 values ranging from 43 to 72 nmol/l. resminostate has the potential to be used for the treatment of multiple myeloma (mm) due to its ability to induce histone h4 hyperacetylation, and apoptosis (ic50 ranging from 2.5 to 3 μmol/l) in mm cells. recent study results have shown that, in mm cell lines, resminostat abrogates cell growth, suppresses proliferation and induce g0/g1 cell cycle arrest as well as interfering with akt signaling pathway by decreasing phosphorylation of 4e-bp1 and p70s6k.mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010; 149(4):518-528.
Check Digit Verification of cas no
The CAS Registry Mumber 864814-88-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,8,1 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 864814-88:
(8*8)+(7*6)+(6*4)+(5*8)+(4*1)+(3*4)+(2*8)+(1*8)=210
210 % 10 = 0
So 864814-88-0 is a valid CAS Registry Number.
864814-88-0Relevant articles and documents
NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC S NOVEL SULPHONYLPYRROLES
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Page/Page column 55-56, (2008/06/13)
Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
