864875-60-5

Basic information

• Product Name: tert-butyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-thiomorpholine-3-carboxylate
• Synonyms: tert-butyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-thiomorpholine-3-carboxylate
• CAS NO: 864875-60-5
• Molecular Weight: 411.543
• Mol File: 864875-60-5.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-thiomorpholine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-thiomorpholine-3-carboxylate(864875-60-5)
• EPA Substance Registry System: tert-butyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-thiomorpholine-3-carboxylate(864875-60-5)

Safety Data

• Hazardous Substances Data: 864875-60-5(Hazardous Substances Data)

Upstream product

• 97170-10-0 S-hydroxyethylcysteine 

Relevant articles and documents

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates

The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1′ group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.

ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS

Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.