864875-65-0

Basic information

• Product Name: 1-(4-but-2-ynyloxy-benzenesulfonyl)-4-(thiophene-2-carbonyl)-piperazine-2-carboxylic acid ethyl ester
• CAS NO: 864875-65-0
• Molecular Weight: 476.574
• Mol File: 864875-65-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-but-2-ynyloxy-benzenesulfonyl)-4-(thiophene-2-carbonyl)-piperazine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-but-2-ynyloxy-benzenesulfonyl)-4-(thiophene-2-carbonyl)-piperazine-2-carboxylic acid ethyl ester(864875-65-0)
• EPA Substance Registry System: 1-(4-but-2-ynyloxy-benzenesulfonyl)-4-(thiophene-2-carbonyl)-piperazine-2-carboxylic acid ethyl ester(864875-65-0)

Safety Data

• Hazardous Substances Data: 864875-65-0(Hazardous Substances Data)

Upstream product

• 287407-79-8 1-(4-but-2-ynyloxy-benzenesulfonyl)-piperazine-2-carboxylic acid ethyl ester 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 183742-29-2 piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 287403-51-4 4-(4-but-2-ynyloxy-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 

Relevant articles and documents

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates

The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1′ group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.