86492-19-5

Upstream product

• 85-44-9 phthalic anhydride 
• 19060-15-2 4-aminobutyraldehyde dimethyl acetal 

Downstream Products

• 94830-02-1 2-{4-[(4-Chloro-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94830-00-9 2-{4-[(4-Methoxy-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94829-99-9 2-methoxy-5-nitrophenylhydrazone of γ-phtalimidobutyraldehyde 

Relevant academic research and scientific papers

Synthesis of phosphorus isosters of β-amyloid peptides fragments

We have developed a synthetic route to pseudo dipeptides, analogs of certain fragments of β-amyloid peptides (products of the APP protein hydrolysis). These compounds can be used for preparation of phosphinic acidic oligopeptides representing the peptide sequence of the β-amyloid but containing the phosphorus isoster peptide fragment. Synthesis of pseudo ornityl-glutamate, pseudo arginyl-glutamate, pseudo glycyl-leucine, and pseudo isoleucyl-glycine via amino- and amidoalkylation of phosphonic acids containing the structural isoster of the corresponding amino acid is described.