864925-98-4

Basic information

• Product Name: ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
• CAS NO: 864925-98-4
• Molecular Weight: 387.459
• Mol File: 864925-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate(864925-98-4)
• EPA Substance Registry System: ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate(864925-98-4)

Safety Data

• Hazardous Substances Data: 864925-98-4(Hazardous Substances Data)

Upstream product

• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 103-82-2 phenylacetic acid 
• 24248-71-3 2-amino-3-aminocarbonyl-4,7-dihydrothieno<2,3-c>pyridine-6(5H)-carboxylic acid ethyl ester 
• 103-80-0 phenylacetyl chloride 

Relevant articles and documents

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonists of the parathyroid hormone receptor. X-ray crystallographic studies of PDE4D2 complexed to four potent inhibitors reveal the atomic details of how they inhibit the enzyme and a notable contrast to another recently reported thiophene-based inhibitor.