864933-93-7Relevant articles and documents
INTRACELLULAR SUBSTANCE TRANSPORT SYSTEM AND USE THEREOF
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, (2020/05/29)
The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.
Efficient regeneration of the 5-acetamido group of a neuraminic acid aryl glycoside from the O-nethyl acetimidate function under acidic conditions
Orlova,Zinin,Kononov
experimental part, p. 442 - 445 (2010/07/09)
Treatment of protected N-acetylneuraminic acid 2-formyl-4-nitrophenyl glycoside with (diethyl-amino)sulfur trifluoride (DAST) and methanol resulted, apart from the known transformation of the formyl group into a difluoromethyl one, in an undocumented form
Neuraminidase inhibitor
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Page/Page column 6-7, (2008/06/13)
This invention relates to a method of treating an infection with an influenza virus. The method includes administering to a subject in need thereof an effective amount of a compound of formula (I): Each variable in this formula is defined in the specifica
Design of a mechanism-based probe for neuraminidase to capture influenza viruses
Lu, Chun-Ping,Ren, Chien-Tai,Lai, Yi-Ning,Wu, Shih-Hsiung,Wang, Wei-Man,Chen, Jean-Yin,Lo, Lee-Chiang
, p. 6888 - 6892 (2007/10/03)
(Chemical Equation Presented) Getting a grip on the flu: A mechanism-based probe, 1, for neuraminidase was developed. It is capable of forming a biotinylated adduct with neuraminidase (NA) from Arthrobacter ureafaciens. It also displays an inhibitory effe