864934-26-9Relevant academic research and scientific papers
Practical synthesis of roscovitine and CR8
Oumata, Nassima,Ferandin, Yoan,Meijer, Laurent,Galons, Herve
experimental part, p. 641 - 644 (2010/04/22)
Roscovitine and CR8 are potent inhibitors of cyclin-dependent kinases. A scalable synthesis of both inhibitors is described. In the case of CR8, the biarylmethylamine moiety was obtained as a stable and high-purity salt.
Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series
Kuduk, Scott D.,Chang, Ronald K.,Ng, Christina,Murphy, Kathy L.,Ransom, Richard W.,Tang, Cuyue,Prueksaritanont, Thomayant,Freidinger, Roger M.,Pettibone, Douglas J.,Bock, Mark G.
, p. 3925 - 3929 (2007/10/03)
SAR study of the biphenyl region of 2,3-diaminopyridine bradykinin B 1 antagonists was investigated with non-aromatic carbo- and heterocyclic rings. A piperidine ring was found to be a good replacement for the proximal phenyl ring while replacement of the distal phenyl was optimal with a cyclohexyl group leading to a dramatic improvement in affinity for the B 1 receptor.
