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CAS

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864963-47-3

3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 864963-47-3 Structure

  • Basic information

    1. Product Name: 3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
    2. Synonyms: 3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
    3. CAS NO:864963-47-3
    4. Molecular Formula:
    5. Molecular Weight: 330.343
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 864963-47-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(864963-47-3)
    11. EPA Substance Registry System: 3-(2-formylphenyl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(864963-47-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 864963-47-3(Hazardous Substances Data)

864963-47-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 864963-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,9,6 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 864963-47:
(8*8)+(7*6)+(6*4)+(5*9)+(4*6)+(3*3)+(2*4)+(1*7)=223
223 % 10 = 3
So 864963-47-3 is a valid CAS Registry Number.

864963-47-3Relevant articles and documents

First efficient synthesis of novel oxophenyl-arcyriaflavin analogs

Bourderioux, Aurélie,Routier, Sylvain,Bénéteau, Valérie,Mérour, Jean-Yves

, p. 6071 - 6074 (2005)

New oxophenylarcyriaflavins were synthesized in a few efficient steps. The key steps involved at first a palladium cross-coupling between the 3-bromo-4-(1H-indol-3-yl)1-methylpyrrole-2,5-dione and the 2-formylphenylboronic acid or a methyl 2-trialkylstann

Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents

Bourderioux, Aurelie,Beneteau, Valerie,Merour, Jean-Yves,Baldeyrou, Brigitte,Ballot, Caroline,Lansiaux, Amelie,Bailly, Christian,Le Guevel, Remy,Guillouzo, Christiane,Routier, Sylvain

scheme or table, p. 2108 - 2194 (2009/02/01)

We report the synthesis and biological evaluation of new oxophenylarcyriaflavins designed as potential anticancer agents. An efficient synthesis involving palladium-catalyzed Suzuki and Stille reactions is presented, without any indolic protective group. The central ring closure of the scaffold was performed through an electrophilic reaction on the position C-2 of the indole ring. The use of indole and 5-benzyloxyindole, along with substituted phenyl rings, generated three different scaffolds, which were successively exploited to modulate the structure. The cytotoxicity of the newly designed compounds on four cancer cell lines and activities against three kinases (CDK1, CDK5 and GSK3) were evaluated. Several compounds showed a marked cytotoxicity with IC50 values in the sub-micromolar range, and induced important cell cycle perturbations, with a G2/M arrest. Some compounds revealed DNA binding properties and were found to inhibit topoisomerase-mediated DNA relaxation of supercoiled DNA, but these properties are not mandatory for a cytotoxic action. A novel lead compound (32) has been identified and warrants further investigations. The Royal Society of Chemistry 2008.

Synthesis of benzo analogs of oxoarcyriaflavins and caulersine

Bourderioux, Aurélie,Routier, Sylvain,Bénéteau, Valérie,Mérour, Jean-Yves

, p. 9465 - 9475 (2008/02/10)

In the course of a program aimed at designing new antitumor agents, we were interested in the synthesis of mixed structures of maleimidophenyl carbazoles and natural product caulersine as potential CDK inhibitors. This was performed through an efficient f

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