864973-52-4Relevant academic research and scientific papers
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists
Clark, Robin D.,Ray, Nicholas C.,Blaney, Paul,Crackett, Peter H.,Hurley, Christopher,Williams, Karen,Dyke, Hazel J.,Clark, David E.,Lockey, Peter M.,Devos, Rene,Wong, Melanie,White, Anne,Belanoff, Joseph K.
, p. 5704 - 5708 (2008/03/13)
The 2-azadecalin ring system was evaluated as a scaffold for the preparation of glucocorticoid receptor (GR) antagonists. High affinity, selective GR antagonists were discovered based on a hypothetical binding mode related to the steroidal GR antagonist R
FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
-
Page/Page column 61-62, (2010/02/14)
The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
