86499-69-6

Basic information

• Product Name: (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester
• Synonyms: (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester;tert-Butyl (2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbaMate;tert-Butyl N-(2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)carbamate
• CAS NO: 86499-69-6
• Molecular Formula: C₁₅H₂₀N₂O₃
• Molecular Weight: 276.3309
• Mol File: 86499-69-6.mol

Chemical Properties

• Boiling Point: 472.5±44.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.34±0.20(Predicted)
• CAS DataBase Reference: (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester(86499-69-6)
• EPA Substance Registry System: (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester(86499-69-6)

Safety Data

• Hazardous Substances Data: 86499-69-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic benefits.
Used in Drug Development:
As a benzo[b]azepine derivative, (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester is utilized in drug development for its potential to modulate biological targets and pathways. Its specific interactions with cellular components may contribute to the discovery of novel therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester serves as a key compound for studying the structure-activity relationships of benzo[b]azepine derivatives. This helps researchers understand the molecular mechanisms underlying their pharmacological effects and optimize their therapeutic potential.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 

Downstream Products

• 958075-42-8 tert-butyl [1-(3,5-difluorobenzyl)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]carbamate 
• 65028-92-4 2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-amine 
• 958075-43-9 3-amino-1-(3,5-difluorobenzyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one hydrochloride 
• 958075-57-5 3-amino-7-phenyl-1,3,4,5-tetrahydro-1-benzazapin-2-one hydrochloride 
• 958075-56-4 tert-butyl (7-phenyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)carbamate 
• 103825-24-7 3-amino-1-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant articles and documents

2-ALKOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINES, THE PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING THE SAME

The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzodiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds, and to intermediate precursors to such compounds.

Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.

Lactam inhibitors of factor Xa and method

Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, 1011 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.