865060-67-9Relevant academic research and scientific papers
Direct catalytic asymmetric mannich-type reactions of N-(2-hydroxyacetyl) pyrrole as an ester-equivalent donor
Harada, Shinji,Handa, Shinya,Matsunaga, Shigeki,Shibasaki, Masakatsu
, p. 4365 - 4368 (2007/10/03)
(Chemical Equation Presented) Stretching the limits of the Mannich reaction: A new indium-binol catalyst was used to generate the enolate of the esterequivalent donor in situ (see scheme). The donor, an N-acyl pyrrole, has many similarities to an aromatic ketone, in particular the enolates should have the same coordination mode. Versatile β-amino-α-hydroxy carboxylic acid derivatives were obtained in high yield and ee values.
