865086-04-0

Basic information

• Product Name: N-(3-phenoxypropyl)-isoindoline
• Synonyms: N-(3-phenoxypropyl)-isoindoline
• CAS NO: 865086-04-0
• Molecular Weight: 253.344
• Mol File: 865086-04-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-phenoxypropyl)-isoindoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-phenoxypropyl)-isoindoline(865086-04-0)
• EPA Substance Registry System: N-(3-phenoxypropyl)-isoindoline(865086-04-0)

Safety Data

• Hazardous Substances Data: 865086-04-0(Hazardous Substances Data)

Upstream product

• 496-12-8 isoindoline 
• 3384-04-1 3-chloropropyl phenyl ether 
• 960372-46-7 4,5,6,7-tetrachloro-2-(3-phenoxypropyl)-2,3-dihydro-1H-isoindole 
• 960372-45-6 5-fluoro-2-(3-phenoxypropyl)-2,3-dihydro-1H-isoindole 
• 83708-38-7 (3-phthalimidopropyl)-phenyl ether 

Downstream Products

• 865086-09-5 N-(3-phenoxypropyl)-4,5,6,7-tetrahydroisoindole 

Relevant articles and documents

Formation of 4,5,6,7-tetrahydroisoindoles by palladium-catalyzed hydride reduction

(Chemical Equation Presented) Substituted 1,3-dihydro-2H-isoindoles (2, isoindolines) were prepared and subjected to palladium-catalyzed formate reduction. Alkyl isoindolines were reduced to 4,5,6,7-tetrahydro-2H-isoindoles (1). Only partial reduction was observed for 5-methoxyisoindoline, and 4-methoxy-, 5-carbomethoxy-, amino-, and amidoisoindolines were inert to the reaction. Halogen-substituted isoindolines were dehalogenated and reduced to 4,5,6,7-tetrahydro-2H-isoindoles. Isoindole 24 was also reduced to a mixture of an isoindoline and a 4,5,6,7-tetrahydro-2H-isoindole. In contrast, 2,3-dihydro-1H-indoles 21 underwent dehydrogenation to give thermodynamically stable indoles. Theoretical calculations show the significant difference in aromaticity between isoindoles and indoles, corresponding to the observed differences in reactivities. Tetrahydro-2H-isoindoles 1 were oxidized to 4,5,6,7-tetrahydroisoindole-1,3-diones in the presence of NBS and air.