865086-56-2Relevant academic research and scientific papers
CHIRAL AMINE-CATALYZED ASYMMETRIC ADDITION OF CARBON-CENTERED NUCLEOPHILES TO IMINES
-
Page/Page column 36-37; 70, (2010/11/25)
The present invention relates to an asymmetric synthesis useful for preparing compounds useful for the treatment of cardiovascular diseases and for studying the role of motor proteins in cell cycle progression.
Asymmetric Mannich reactions of β-keto esters with acyl imines catalyzed by cinchona alkaloids
Lou, Sha,Taoka, Brandon M.,Ting, Amal,Schaus, Scott E.
, p. 11256 - 11257 (2007/10/03)
Cinchona alkaloids catalyze the enantioselective Mannich reaction of β-keto esters with acyl aryl imines. The reaction requires 10 mol % of cinchonine or cinchonidine. The reaction products are obtained in good yields (81-99%), high enantioselectivities (
