86521-11-1 Usage
Uses
Used in Pharmaceutical Synthesis:
3-((TriMethylsilyl)ethynyl)isoquinoline is used as a precursor in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
3-((TriMethylsilyl)ethynyl)isoquinoline also serves as a precursor in the production of agrochemicals, contributing to the development of new pesticides or other agricultural products that can enhance crop protection and yield.
Used in Organic Chemistry Research:
3-((TriMethylsilyl)ethynyl)isoquinoline is utilized as a building block in organic chemistry research, where its properties can be explored and harnessed for the creation of novel organic compounds with diverse applications.
Used in Chemical Modification and Functionalization:
Due to the presence of the ethynyl group, 3-((TriMethylsilyl)ethynyl)isoquinoline is used for further chemical modification and functionalization, allowing scientists to create new derivatives with specific properties tailored for particular applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 86521-11-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,5,2 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 86521-11:
(7*8)+(6*6)+(5*5)+(4*2)+(3*1)+(2*1)+(1*1)=131
131 % 10 = 1
So 86521-11-1 is a valid CAS Registry Number.
86521-11-1Relevant articles and documents
Ru(II) coordination compounds of N[sbnd]N bidentate chelators with 1,2,3 triazole and isoquinoline subunits: Synthesis, spectroscopy and antimicrobial properties
Kreofsky, Nicholas W.,Dillenburg, Maxwell D.,Villa, Eric M.,Fletcher, James T.
, (2019/12/26)
Bidentate chelators 1-(1-benzyl-1,2,3-triazol-4-yl)isoquinoline and 3-(1-benzyl-1,2,3-triazol-4-yl)isoquinoline were prepared from benzyl bromide and trimethylsilylethynylisoquinoline precursors using a tandem deprotection/substitution/CuAAC synthetic approach. Each chelator is capable of forming a stable 3:1 Ru(II) coordination compound, which forms as a geometric isomer mixture. These Ru(II) complexes possess unique MLCT absorbance signatures at 450/472 nm (1-isomer) and 367 nm (3-isomer) relative to their constituent chelating units. Minimum inhibitory concentration values as low as 0.4 μM are observed for Ru(II) complexes against representative Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis. Comparing the MIC values of these isoquinoline compounds with analogous 2-(1-benzyl-1,2,3-triazol-4-yl)pyridine compounds shows a 2.5- to 40-fold improvement in potency. This study establishes that increased hydrophobicity introduced at the central chelating units of Ru(II) coordination compounds can be a useful means by which to optimize antimicrobial activity that is complimentary to the variation of peripheral substituent identity at the chelator's N1 triazole position.
