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• 1122-91-4 4-bromo-benzaldehyde 
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Relevant academic research and scientific papers

Ionic liquid [EMIM]OAc under ultrasonic irradiation towards synthesis of 1,4-DHP's

The ionic liquid 1-ethyl-3-methylimidazole acetate ([EMIM]OAc) was found to be a mild and effective catalyst for the efficient, one-pot, three-component synthesis of 1,4-dihydropyridines from arylalde-hydes, ethylacetoacetate/ acetylacetone and ammonium acetate at room temperature under sonication. The developed method has many advantages, including devoid of harmful catalysts, reacting at room temperature, higher yields in a simple methodology or operational convenience.

Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies

The present study aims to first explore the relationship between the chemical structure of the organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities, as well as the impact of substituent effects on their antibacterial properties. These compounds were synthesized by efficient methods, and their structures confirmed by the spectral methods (IR, 1H NMR, 13C NMR and elemental analysis). The antibacterial activities of synthesized the compounds were checked with five Gram-positive and Gram-negative strains such as Enterobacter cloacae (ATCC29893),Escherichia coli (ATCC35218), Klebsiella pneumoniae (ATCC13883), Staphylococcus aureus (ATCC29213) and Acinetobacter baumannii (ATCC19606). The results of the antibacterial activities of four synthesized compounds were compared with three standard antibiotics [Penicillin G, Erythromycin and Norfloxacin (quinoline type)]. The minimum inhibitory concentrations (MICs) of active compounds were calculated and discussed. The chemical and biological activities of hydroxyquinoline derivatives were compared with theoretical methods. The chemical activities of hydroxyquinoline derivatives were contrasted with the important quantum chemical parameters using the HF/6–31++g (d, p) basis sets. Besides, biological activities of hydroxyquinoline derivatives against cancer proteins that are respectively protein of the BRCT repeat region of breast cancer that is ID: 1JNX, crystal structure of liver cancer protein that is ID: 3WZE, and crystal structure of lung cancer protein that is ID: 5ZMA, were compared. ADME/T (Adsorption, Distribution, Metabolism, Excretion, and Toxicity) analysis was studied for molecules with high biological activity to become efficient drugs in the future.

Ultrasound-mediated, uranyl nitrate hexahydrate-catalyzed synthesis of 1,4-dihydropyridines under mild conditions

Abstract Synthesis of 1,4-dihydropyridines by three-component condensation reaction of aldehyde, 1,3-dicarbonyl compounds, and ammonium acetate have been found to be efficiently catalyzed by uranyl nitrate hexahydrate [UO2(NO3)2 ·6H2O] at room temperature under ultrasound irradiation. This novel synthetic method offers the advantages of high yields, short reaction times, simplicity, and easy workup compared to the conventional methods reported in the literature.

Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters

A series of symmetrical and unsymmetrical 1,4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compound

Etidronic acid catalyzed synthesis of 1,4-dihydropyridines

One pot, three components cyclaconctensation reaction of various arylaldehydes. ethyl acetoacetate/acetyl acetone and ammonium acetate with etidronic acid as catalyst afforded the corresponding 1,4 -dihydropyridines in better yields under solvent free conditions.

Etidronic acid catalyzed synthesis of 1,4-dihydropyridines

One pot, three components cyclocondensation reaction of various arylaldehydes, ethyl acetoacetate/acetyl acetone and ammonium acetate with etidronic acid as catalyst afforded the corresponding 1,4-dihydropyridines in better yields under solvent free conditions.