865300-93-2

Upstream product

• 102191-92-4 tert-butyldimethylsiloxyacetaldehyde 
• 140-75-0 para-fluorobenzylamine 
• 22116-33-2 2-(4-fluoro-benzyl-amino)-ethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 101711-55-1 2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine 

Downstream Products

• 895134-22-2 4-benzyloxy-3-methoxy-pyridine-2-carboxylic acid [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-(4-fluoro-benzyl)-amide 
• 1616924-78-7 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](4-fluorobenzyl)amide 
• 922159-46-4 5,6-bis-(4-methoxy-benzyloxy)-2-p-tolyl-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-(4-fluoro-benzyl)-amide 

Relevant academic research and scientific papers

Photocatalyzed cascade Meerwein addition/cyclization of: N -benzylacrylamides toward azaspirocycles

A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C-F bond cleavage was developed. This method offers a rapid access to azaspirocyclic cyclohexadienones from N-benzylacrylamides via C-F bond cleavage applying H2O as an external oxygen source, allowing for the incorporation of various aromatic moieties originating from aryldiazonium salts.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

ANTIVIRAL COMPOUNDS

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE

Bi-or tricyclic compounds of formula (I) wherein R1, R4 and R5 are as herein defined, A represents a single or double bond and two R2, R2’, R3 and R3’ can be joined to form a condensed or spiro ring. These compounds and their pharmaceutical acceptable salt are used in combinations or pharmaceutical compositions and are useful in methods for preventing or treatin human immunodeficiency virus (HIV) infection or in methods for preventing, delaying or treating acquired immunodeficiency syndrome (AIDS).

HIV INTEGRASE INHIBITORS

Pyridopyrazine- and pyrimidopyrazine-dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I); wherein G, Q, bond a, R5, R6 and R