865304-71-8

Basic information

• Product Name: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine
• Synonyms: EOS-61050
• CAS NO: 865304-71-8
• Molecular Formula: C₁₄H₁₈N₄O₂
• Molecular Weight: 274.31832
• Mol File: 865304-71-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(865304-71-8)
• EPA Substance Registry System: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(865304-71-8)

Safety Data

• Hazardous Substances Data: 865304-71-8(Hazardous Substances Data)

Usage

General Description

5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine is a chemical compound with the molecular formula C14H18N4O2. It is a derivative of pyrimidine and contains a 2,4-diaMine group. The compound also features a phenoxy group with an isopropyl and methoxy substituent. This chemical may be used in various research and industrial applications, such as in the synthesis of pharmaceuticals or agrochemicals. It may also have potential biological activities that make it of interest in the field of drug discovery and development. Further studies are likely necessary to fully understand the properties and potential uses of this chemical compound.

Upstream product

• 593-85-1 diguanidine carbonate 
• 50-01-1 guanidine hydrochloride 
• 4761-93-7 imidodicarbonimidic diamide hydrochloride 
• 927872-64-8 2-(2-isopropyl-4-methoxyphenoxy)acetonitrile 
• 13522-86-6 2-iso-propyl-4-methoxyphenol 
• 1004-01-9 5-bromopyrimidine-2,4-diamine 
• 927887-20-5 2-(2-isopropyl-4-methoxyphenoxy)-3-phenylaminoacrylonitrile 
• 109-94-4 formic acid ethyl ester 
• 1145716-61-5 C₁₄H₁₇NO₃ 

Downstream Products

• 865305-61-9 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonyl chloride 
• 1145715-92-9 5-(5-chloro-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 
• 865304-65-0 4-(2,4-diamino-pyrimidin-5-yloxy)-2-iodo-5-isopropyl-phenol 
• 865305-31-3 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzonitrile 
• 865305-75-5 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-thiobenzamide 
• 865304-45-6 1-[5-(2,4-diamino-pyrimidine-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-ethanol 
• 865304-43-4 2-[5-(2,4-diaminopyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-propan-2-ol 
• 865305-30-2 [3H]-AF-353 

Relevant articles and documents

Development of a green and sustainable manufacturing process for gefapixant citrate (MK-7264) Part 3: Development of a one-pot formylation-cyclization sequence to the diaminopyrimidine core

The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic understanding of the cyclization step in the presence of guanidine was established by performing isotopic labeling experiments and identification of impurities. Guided by the mechanistic understanding, further attempts to modify the cyclization reaction by employing additives to reduce the triazine (9) formation and guanidine loading will also be presented. This newly developed method delivered compound 1 in 88-94% yield on a commercial scale and addressed the shortcomings of the early synthetic route including high PMI, low atom economy, long cycle-time, and multiple purifications to achieve the desired quality.

NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND

Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one emb

Process for synthesis of phenoxy diaminopyrimidine derivatives

-