865444-41-3Relevant articles and documents
[2,3]-Wittig rearrangement by a chlorine-lithium exchange
Maciá, Beatriz,Gómez, Cecilia,Yus, Miguel
, p. 6101 - 6104 (2007/10/03)
The reaction of different allylic chloromethyl ethers 1 with an excess of lithium powder (1:7 molar ratio) and a catalytic amount of DTBB (2.5 mol %) in THF at 0°C for 1 h gives, after hydrolysis with water, the expected alcohols 2 resulting from a [2,3]-Wittig rearrangement, in an exclusive manner. The same process can also be applied to the corresponding [1,2]-Wittig rearrangement, as it is exemplified for benzyl chloromethyl ether.