865460-03-3

Basic information

• Product Name: C₂₈H₄₇N₃O₆S
• Synonyms: C₂₈H₄₇N₃O₆S
• CAS NO: 865460-03-3
• Molecular Weight: 553.764
• Mol File: 865460-03-3.mol

Chemical Properties

• CAS DataBase Reference: C₂₈H₄₇N₃O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₄₇N₃O₆S(865460-03-3)
• EPA Substance Registry System: C₂₈H₄₇N₃O₆S(865460-03-3)

Safety Data

• Hazardous Substances Data: 865460-03-3(Hazardous Substances Data)

Upstream product

• 865460-02-2 C₂₉H₄₉N₃O₆S 

Downstream Products

• 865460-04-4 C₃₅H₅₉N₅O₇S 

Relevant articles and documents

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups

Blood borne hepatitis C infections are the primary cause for liver cirrhosis and hepatocellular carcinoma. HCV NS3 protease, a pivotal enzyme in the replication cycle of HCV virus has been the primary target for development of new drug candidates. Boceprevir and telaprevir are two novel ketoamide derived inhibitors that are currently undergoing phase-III clinical trials. These inhibitors include ketoamide functionality as serine trap and have an acidic alpha-ketoamide center that undergoes epimerization under physiological conditions. Our initial attempts to arrest this epimerization by introducing quaternary amino acids at P1 had resulted in significantly diminished activity. In this manuscript we describe alpha quaternized P1 group that result in potent inhibitors in the enzyme assay and demonstrate cellular activity comparable to boceprevir.

SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.