865528-39-8

Basic information

• Product Name: C₂₃H₂₀ClFN₄O₃
• Synonyms: C₂₃H₂₀ClFN₄O₃
• CAS NO: 865528-39-8
• Molecular Weight: 454.888
• Mol File: 865528-39-8.mol

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₀ClFN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₀ClFN₄O₃(865528-39-8)
• EPA Substance Registry System: C₂₃H₂₀ClFN₄O₃(865528-39-8)

Safety Data

• Hazardous Substances Data: 865528-39-8(Hazardous Substances Data)

Upstream product

• 865451-72-5 (3R,4R)-4-(4-chlorophenylcarbamoyl)pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 536747-52-1 1-(4-amino-3-fluoro-phenyl)-pyridin-2-one 

Relevant articles and documents

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663