865532-69-0

Basic information

• Product Name: 5S-hydroperoxy, 18R/S-hydroxy-EPE
• CAS NO: 865532-69-0
• Molecular Weight: 350.455
• Mol File: 865532-69-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5S-hydroperoxy, 18R/S-hydroxy-EPE(CAS DataBase Reference)
• NIST Chemistry Reference: 5S-hydroperoxy, 18R/S-hydroxy-EPE(865532-69-0)
• EPA Substance Registry System: 5S-hydroperoxy, 18R/S-hydroxy-EPE(865532-69-0)

Safety Data

• Hazardous Substances Data: 865532-69-0(Hazardous Substances Data)

Upstream product

• 141110-17-0 (±)-18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid 

Downstream Products

• 865532-70-3 resolvin E2 

Relevant articles and documents

USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA

The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful ;isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.