865536-65-8

Basic information

• Product Name: 4-Oxo-N-(4-hydroxyphenyl)retinamide
• Synonyms: 3-Keto fenretinide;4-Oxofenretinide;4-Oxo-N-(4-hydroxyphenyl)retinamide;4-Keto-4-HPR;4-Oxo-4-HPR;N-(4-Hydroxyphenyl)-4-oxoretinaMide
• CAS NO: 865536-65-8
• Molecular Formula: C26H31NO3
• Molecular Weight: 405.53
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Retinoids;Metabolite&impurity
• Mol File: 865536-65-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 233-235?C
• Boiling Point: 641.8 °C at 760 mmHg
• Flash Point: 341.9 °C
• Appearance: /
• Density: 1.131 g/cm³
• Vapor Pressure: 4.56E-17mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Methanol
• PKA: 9.98±0.26(Predicted)
• CAS DataBase Reference: 4-Oxo-N-(4-hydroxyphenyl)retinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxo-N-(4-hydroxyphenyl)retinamide(865536-65-8)
• EPA Substance Registry System: 4-Oxo-N-(4-hydroxyphenyl)retinamide(865536-65-8)

Safety Data

• Hazardous Substances Data: 865536-65-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

The active metabolite of Fenretinide (4-HPR) (F250000).

InChI:InChI=1/C26H31NO3/c1-18(9-14-23-20(3)24(29)15-16-26(23,4)5)7-6-8-19(2)17-25(30)27-21-10-12-22(28)13-11-21/h6-14,17,28H,15-16H2,1-5H3,(H,27,30)/b8-6+,14-9+,18-7+,19-17+

Relevant articles and documents

4-OXO-FENRETINIDE, ADMINISTERED ALONE AND IN COMBINATION WITH FENRETINIDE, AS PREVENTIVE AND THERAPEUTIC AGENT FOR CANCER

A drug based on a metabolite of fenretinide, or N-(4-hydroxyphenyl)retinamide (4-HPR), specifically 4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR), is used in the treatment of different kinds of tumors, in particular in the treatment of ovarian carcino