86555-32-0Relevant academic research and scientific papers
Fungicidal activity of truncated analogues of dihydrosphingosine
Thevissen, Karin,Hillaert, Ulrik,Meert, Els M.K.,Chow, Kuen K.,Cammue, Bruno P.A.,Van Calenbergh, Serge,Francois, Isabelle E.J.A.
, p. 3728 - 3730 (2008)
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.
