86557-77-9Relevant academic research and scientific papers
Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles
Qi, Bing,Li, Lei,Wang, Qi,Zhang, Wenjing,Fang, Lili,Zhu, Jin
supporting information, p. 6860 - 6863 (2019/09/12)
We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.
SUBSTITUTION AND ADDITION REACTIONS OF ISOINDOLES
Bonnett, Raymond,North, Stephanie A.,Newton, Roger F.,Scopes, David I. C.
, p. 1401 - 1406 (2007/10/02)
1-Phenylisoindole reacts with toluene-p-diazonium chloride to give the azo derivative formed by electrophilic substitution at the free α position.However, attempted nitrosation of 1-phenylisoindole gave the product (3) of oxidative dimerisation, while the
