86557-79-1Relevant academic research and scientific papers
Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts
Xu, Ke,Li, Wenjing,Sun, Rui,Luo, Lihua,Chen, Xue,Zhang, Chunchun,Zheng, Xueli,Yuan, Maolin,Fu, Haiyan,Li, Ruixiang,Chen, Hua
supporting information, p. 6107 - 6111 (2020/08/12)
The first I2-mediated synthesis of 2-formylpyrroles from pyridinium salts is reported. This protocol enables the synthesis of diversely substituted 2-formylpyrroles in good yields under operationally simple conditions. The detailed mechanistic studies reveal that the reaction proceeds via a novel H2O-triggered ring opening of the pyridinium salt and a subsequent intramolecularly nucleophilic addition sequence.
Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles
Qi, Bing,Li, Lei,Wang, Qi,Zhang, Wenjing,Fang, Lili,Zhu, Jin
, p. 6860 - 6863 (2019/09/12)
We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.
Synthesis and X-Ray Crystal Structures of 1-(NN-Dimethylaminomethylidene)-3-phenylisoindolenine and 1-Formyl-3-phenylisoindole
Bonnett, Raymond,Hursthouse, Michael B.,North, Stephanie A.,Trotter, Jill
, p. 833 - 840 (2007/10/02)
1-Phenylisoindole reacts with the Vilsmeier reagent to give 1-(NN-dimethylaminomethylidene)-3-phenylisoindole (4), which on basic hydrolysis furnishes 1-formyl-3-phenylisoindole (5).X-Ray structure analyses have been carried out on (4) and (5).The latter
